Compound
The composition includes the active ingredient drotaverine hydrochloride .
1 tablet contains 40 or 80 mg of this substance. Additional elements: talc, potato starch, povidone, magnesium stearate, lactose monohydrate.
1 ml of injection solution contains 20 or 40 mg of active substance.
1 ml of solution for IV and IM contains 20 or 40 mg of active substance, as well as additional elements: injection water, sodium disulfite and ethanol.
How to use "Drotaverine" in solution
When administered intramuscularly, adults are prescribed 2 to 4 ml three times a day. For colic and spasms of the liver or kidneys, intravenous use of the solution is recommended, which must be administered slowly. In exceptional cases, in case of circulatory problems, the medicine is injected into the artery.
For women during childbirth, the solution is injected into the muscle in a volume of 2 ml. If necessary, repeat the procedure after two hours. For intestinal and stomach ulcers, the drug is used in conjunction with antiulcer medications.
Pharmacodynamics and pharmacokinetics
Compared to papaverine, it has a longer and more pronounced effect, despite the similarity in pharmacological properties and chemical structure. The mechanism of action is aimed at reducing the flow of calcium into smooth muscle tissue. Drotaverine hydrochloride dilates blood vessels, reduces intestinal motility , and the tone of smooth muscle tissue of internal organs. The drug does not affect the functioning of the autonomic nervous system and does not pass through the blood-brain barrier . The drug is prescribed when it is impossible to use m-anticholinergic drugs. When administered intravenously, the effect develops after 4 minutes, the maximum is recorded after half an hour. It is excreted to a greater extent by the kidneys and to a lesser extent by bile.
Possible side effects
Side effects from taking Drotaverine can occur in two cases: if it is taken for too long or if an allergic reaction to any component occurs. Such actions include the following manifestations:
- gastrointestinal tract - belching, constipation (or vice versa diarrhea), feeling of nausea, vomiting;
- central nervous system – fainting, severe headaches, disrupted daily routine, sleep disturbances;
- respiratory tract – swelling of the mucous membranes or bronchospasms;
- allergic reactions - Quincke's edema, dermatitis, rash, excessive sweating, itching;
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All the described effects occur both when taking tablets and after injections, however, in the latter case, the patient may begin to develop depressed breathing, hypotension, or atrioventricular block (impaired conduction of electrical impulses from the atria to the ventricles).
It is important to follow the dosage of the drug, otherwise side effects may occur.
If you have headaches while taking Drotaverine or one of these side effects has been noted, and especially after injections, then the course of treatment should be stopped and you should consult your doctor. He will be able to either select analogues or prescribe additional medications to eliminate these actions.
Indications for use of Drotaverine
Drotaverine solution and tablets - what are they for? The drug is prescribed for the prevention and treatment of biliary dyskinesia, biliary colic , spasm of smooth muscle tissue, gallbladder dyskinesia , cholecystitis, pyelitis, postcholecystectomy syndrome, intestinal colic, pilospasm, proctitis, spastic colitis, spastic constipation , gastroduodenitis. Often used during menstruation.
What else does the medicine Drotaverine help with? Indications for use of the drug are also: vasospasm, endarteritis, postpartum contractions, prolonged opening of the pharynx, spasm of the pharynx during delivery, threatened miscarriage, algodismenorrhea , cholecystography.
Contraindications
- hypersensitivity to the components of the drug,
- congenital lactose intolerance,
- lactase deficiency,
- heart failure,
- renal and liver failure.
- childhood
- lactation period.
Caution should be used in patients with low blood pressure, severe atherosclerosis of the coronary arteries, closed-angle glaucoma, prostatic hyperplasia, and during pregnancy.
Instructions for use of Drotaverine (Method and dosage)
Drotaverine tablets, instructions for use
The medicine is prescribed to adults three times a day orally, 40-80 mg. No more than 240 mg.
Drotaverine injections, instructions for use
40-80 mg is administered subcutaneously and intravenously 1-3 times a day. In order to relieve renal and hepatic colic, 40-80 mg is administered intravenously slowly. Intra-arterial administration is acceptable for peripheral vascular spasm.
For children
Children from 3 years to six years of age can be administered 10-20 mg at a time, no more than 120 mg per day. 2-3 doses per day are acceptable.
During pregnancy and lactation
Medications from the group of antispasmodics are allowed to be taken during early pregnancy. The dose is prescribed only by the doctor after examining the woman. It is not recommended to take the medicine in the later stages, as the active ingredients lead to softening of the cervix. When breastfeeding, you cannot take pills or give injections. There is no data on exposure to milk. In case of strict indications, lactation is interrupted for the period of treatment.
Taking Drotaverine is allowed in the early stages of pregnancy. The dose of the medicine is prescribed by the doctor.
Interaction
The drug can weaken the effect of antiparkinsonian drugs (for example, levodopa). The drug enhances the effectiveness of antispasmodics, bendazole , papaverine. When taking procainamide, tricyclic antidepressants , and quinidine simultaneously, a drop in blood pressure is recorded. Reduces the spasmogenic effect of morphine. Phenobarbital enhances the effect of the drug.
Analogs
Level 4 ATC code matches:
Spasmol
No-Shpa
Drotaverine Hydrochloride
Papaverine
Analogues of the medicine are Dolce , Drotaverine Hydrochloride , No-Shpa , Spazoverine .
What is better Drotaverine or No-shpa?
The drugs are generally similar, since they have a similar effect and the same active substance. So Drotaverine is No-shpa, essentially the same. However, No-shpa is a more expensive product, since it is of imported origin.
When choosing No-shpa or Drotaverine, you should also remember that the latter is not a patented medicine.
What do Drotaverine tablets help with?
The effect of the drug is especially strong in the area of the stomach and intestines, the urinary and reproductive systems, as well as the biliary tract.
Since the drug has an antispasmodic effect, the result of taking it is the relaxation of the smooth muscles of organs and organ systems and the spasm, which results in pain, goes away. To summarize, Drotaverine can be called a universal analgesic for pain and spasms in the gastrointestinal tract, genitourinary system and biliary tract.
The concomitant effect of lowering pressure and expanding the vascular system is explained by the fact that drotaverine relaxes the muscles of blood vessels as well.
Drotaverine price, where to buy
The price of Drotaverine in 40 mg tablets is 20 rubles per pack of 20 pieces.
Drotaverine Forte 80 mg costs 50 rubles per pack of 20 pieces.
10 ampoules of 2 ml each cost 60 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
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Pharmacy24
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